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    • 专利摘要:
    The method of obtaining the 1,1,2-triphenylpropene derivatives of Formula I eGs-c c- / Wo-cng-cng-rs And where X and y may be the same or different and each means unsubstituted or substituted in the H-position of OXI-, methoxy methoxy-C l-alkoxy or benzyloxy groups phenyl; R2 and R are hydrogen, C.-alkyl or -oxyalkyl or together with the 2-A atom of nitrogen form a morpholine group, as a mixture of isomers or trans-isomer or their salts, characterized in that the compound of formula II CGS-C- / ) where X and Y have the indicated meanings, with the exception of the hydroxy groups, are reacted with an alkaline amino acid alkali metal of the formula R2 of l-sn2-cH2-1; Ks § where M is alkali metal; CLI R, have the indicated values, in the medium of a bipolar aprotic plant. solvent, such as dimethylacetamide, at 140-180 ° C, and if necessary, heat methoxy-methoxy- or benzylCO2; hydroxy group under acidic conditions, and make up the desired product as a mixture of iso-N9 measures or trans-isomer as free compound or salt.
    公开号:SU1114332A3
    申请号:SU813344199
    申请日:1981-10-16
    公开日:1984-09-15
    发明作者:Абрахам Гизелла；Хорват Тибор；Толдь Лайош；Борвендег Янош；Чаньи Эндре；Кишш Ева；Сенте Илона；Тори Кальман
    申请人:Эдьт Дьедьсерведьесети Дьяр (Инопредприятие)；
    IPC主号:
    专利说明:

    The method of obtaining 1,1,2-triphenyl propene derivatives as a mixture of isomers or trans-isomer, or their salts. This invention relates to a process for the preparation of new 1,1,1triphenyl propene derivatives having headlamp acological activity. It is known that some derivatives of triphenylalkenes containing the main substituents at the aromatic ring possess anti-estrogenic activity. Two of the most important representatives of this group of compounds are clomiphene (2-diethylaminoethi-2-phenyl -1,2-diphenyl-2-chloroethylene and tamoxifenG (g) -1 - 4- (2-dimethylamino-1-oxy) -phenyl -1, 2-diphenyl-1-butene Q. Although both compounds have anti-estrogenic properties, the first is taken to cause ovulation, and tamoxifen, on the contrary, is primarily treatment of breast tumors. With prolonged use of both compounds, undesirable side effects, namely deterioration of vision, are observed. The purpose of the invention is a method of producing new compounds with anti-estrogenic activity, which in their action are superior to known derivatives, have a specific effect and have very little side effects. . This goal is achieved by the preparation of 1,1,2-triphenyl propene derivatives of the formula CF, -C C- / Vo-CHo-CHo-1) -0-CH2-CH2-NC where X and Y may be the same or different and each means unsubstituted or substituted in the P-position of the Institute of Oxy-, methoxy-methoxy, C.-alkoxy- or benzo-hydroxy, phenyl; R and R-J hydrogen, C |, -alkyl or Ci A-OKCHanKHn or together with the nitrogen atom form a morpholine group, as a mixture of isomers or trans-isomer or their salts. The method of obtaining compounds of formula I is based on the known reaction of the interaction of mixed esters of halides with alkali metal alkoxides (Wilson reaction) 2 and consists in the compound of formula II where X and Y have the indicated values, with the exception of hydroxy groups, are reacted with an alkali metal alkali metal of the formula HO-CH2-CH2-1 where M is an alkali metal; Rj and R have the indicated meanings, in a medium of a bipolar aprotic solvent, such as dimethylacetamide, at 140-180 ° C, and, if necessary, followed by cleavage, of methoxy methoxy or benzyloxy groups under acid conditions, the target product is given in the form of a mixture of isomers or trans isomer in free form or in salt form. Example 1. Preparation of 1- 4- (2-dimesh1-amino-ethoxy) phenes-1-phenyl-3, 3,3-trifluoro-2- (4-methoxyphenyl) -propene. 0.39 g (0.017 g-atom) of sodium is dissolved in 3.12 g (35 mmol) of 2 dimethylaminoethanol, after which 3.15 g (8.5 mmol) of 1-phenyl-3, 3,3-trifluoro is added - 1- (4-fluorofensch1) -2- (4-methoxy-nef-NIL) -propane, and the reaction mixture is heated at 150-155 ° C for one hour. The reaction mixture is cooled, diluted with 200 ml of ether, washed to neutrality with water and dried. The solution is evaporated, the residue is dissolved in 30 MP of hexane, filtered and evaporated once more. 3.39 g (90%) of a gummy product is obtained which consists of a mixture of 3: 4 Z- and E-isomers. CjeHj FjNOg Calculated,%: C, 70.73; H 5.94; F 12.91; N 3.17. Found,%: C 7U, 65; H 6.07; P 13.05; And 3.26. Used as the starting material, 1-phenyl-3, 3,3-trifluoro-1- (4-fluorophenyl) -2 (4-methoxyphenyl) -propene was prepared as follows: 4-methoxy-2, 2,2-trifluoroacetophenone in ethanol in the presence of ethylate, sodium is reacted with triphenyl- (4-fluorobenzyl) phosphonium chloride. I get: 3,3,3-trifluoro-1- (4-fluorophenyl) -2- (4-methoxyphenyl) -propene in 87% yield, kip. 138-142 0 / 0.5 mm Hg The product obtained is hydrogenated in the presence of palladium on carbon as a catalyst. 3,3,3-Trifluoro-1- (A-fluorophenyl) -2- (4-methoxyphenyl) propane is obtained with a yield of 93%, bp 134-136 C / 0.4 mm Hg. st, which is bromered in carbon tetrachloride. After crystallization from hexane, the resulting 1-bromo-3,3,3-trifluoro-1- (4-fluorophenyl) -2- (4-methoxyphene 1) prop (mixture of isomers) melts at 73-94 yield 49%. The resulting product enters into the interaction with benzene in the presence of aluminum trichloride. The resulting 1-phenyl-3,3,3-trifluoro-1- (4-fluorophenyl) -4- (4-methoxyphenyl) propene is crystallized from isopropanol. T. pl. the first fraction (mixture: isomers) is 126-145 ° C. The mother liquor is evaporated at the fifth part of the initial volume. The second fraction (mixture of isomers) is melted at 102-110 ° C. These first and second fractions are combined and boiled with 2,3-dichloro-5,6-di-1-1-1,4-benzoquinone for 120 hours. Obtained 1 -fensch-3,3,3-trifluoro-1- (4-fluorofensch1) -2- (4-methoxyfensch1) -propene crystallizes with rz isopropanol, t, pl. 113-120 C, in the course of 62%. Example 2. Getting 1- |% - (2-dimethylaminoethoxy) -phent1 -2-phenyl-3, 3, H-trifluoro-1- (4-methoxyphensh1) -cene. 0.46 g (0.02 g-atom) of sodium is diluted with 4.5 g (50 mmol) of 2-dimethylaminoethanol. After the addition of 3.72 g (10 mmo) of 2-phenyl-3,3,3-trifluoro-1- (4-fluorophenyl) -1- (4-methoxyphenyl) -propene, the reaction mixture is heated for one hour at 150-155i C and treat but Example 1. 3.95 g (89.6%) of the title compound are obtained. The product is a mixture of 9: 1 Z- and E-isomers. Cj.H FjNOg Calculated,%: C, 70.73; H 5.94; R 12.91; N 3.17. Found,%: C 70.50; H 6.11; F 12.73; N 2.91. Used as the starting material, 2-fennl-3,3,3-trifluoro-1- (4-fluorophenyl) -1- (4-methoxyphenyl) -prop semi-alcohol | ayut as follows: 2gphenyl-3, 3,3-trifluoro- 1- (4-fluorophenyl) -1- (4-methoxyphenyl) propane is boiled for 8 hours with 2,3-dichloro-5,6-dicyano-1, 4-benzoquinone, the resulting product is crystallized from ethanol. Yield 51%, mp. 52-56 ° C. Example 3. Obtaining (2-dimethylaminoNoethoxy) -phenyl -1-phenyl-3, 3,3-trifluoro-2- (4-hydroxyphenyl) -propene hydrochloride. 0.76 g (1.62 mmol) of (2-dimethylaminoethoxy) -phenyl -1-phenyl-3,3,3-trifluoro-2- (4-methoxy-methoxyphenyl) -propene is dissolved in 8 ml of 1% methanol and heated for half an hour. The solution is extruded and the product is crystallized from isopropanol. Obtain 0.56 g (74%) of the title compound with m.p. 196-220 C. Used as starting material (2-dimethylaminoethoxy) -phenyl1-1-phenyl-3, 3,3-trifluoro-2-4- (methoxy-methoxy) -phenyl-propene was prepared according to example 1, Example 4 Preparation of (2-dimethylaminoethoxy) phenyl-2-phenyl-3, 3,3-trifluoro-1- (4-hydroxyphenyl) propene. 2.06 g (4.56 mmol) of 1- (4-benzyloxyphenyl) -1-4- (2-dimethylaminoethoxy) -. α-phenylJ-2-phenyl-3, 3,3-trifluoropropene is dissolved in 45 ml of acetic acid and hydrogenated in the presence of 10% palladium on carbon as a catalyst. The catalyst is filtered off, the filtrate is evaporated, and the residue is crystallized from ether. 0.77 g (39.5%) of the title compound is obtained with a mp. 149-155 C. Used as starting material 1- (4-benzsh10xifefenil) -1-4- (2-dimethylaminoethoxy) -fe mn -2-phenyl-3,3,3-trifluoropropene was prepared as in Example 1. Example 5. Obtaining (2-dimethylaminoethoxy) -phenyl | -3,3,3-trifluoro-1, 2-bis- (4-methoxyphenyl) -propene. 0.46 g (0.02 g-atom) of sodium is dissolved in 3.56 g of 2-dimethylaminoethanol, after which the mixture is mixed with 4.02 g (10 mmol) of 1- (4-fluorophenyl) -3,3,3- trifluoro-1,2-bis (4-methoxyphenyl) -propene and heated at an hour. The reaction mixture is cooled, diluted with 200 ml of ether, washed with water until neutral, and dried. The solution is evaporated, the residue is crystallized from 45 ml of hexane. 51 g of 3.43 g (73%) of the title compound are obtained with a m.p. 77-79 ° C. The starting material is obtained from 1-bromo-3, 3,3-trifluoro-1- (4-fluorofensch1) -2- (4-methoxy-phenyl) -propane as follows; to a solution of 56.6 g (0.15 mol) of 1-bromo-3,3,3-trif1or-1- (4-fluorophenyl) -2- (4-methoxyphenyl) propane in 570 ml of anisole at 6 ° C and stirring 20 g, (0.15 mol) of anhydrous aluminum trichloride are added. The reaction mixture was left overnight at room temperature, then poured onto a mixture of 600 g of ice and 100 ml of 36% hydrochloric acid and extracted with 500 ml of chloroform. The organic phase is washed with sodium bicarbonate and water, dried and the solution is concentrated. The residue is crystallized from 240 ml of isopropanol. Get it. 34.6 g (57%) of 1- (4-fluorophenyl) -3.3.3 trifluoro-1, 2-bis- (4 methoxyphenyl) -propane with m.p. 132-135 ° C. 12.13 g (30 mmol) of the obtained product are boiled under stirring for 16 hours in 60 ml of anhydrous benzene from 13.62 g (60 mmol) of 2, 3-dichloro-5,6-dicyano-1, 4-benzoquinone 8.75 g (72.5%) of 1- (4-fluorophenyl) -3,3,3-trifluoro-1, 2-bis- (4-methoxy-phenyl) propene are obtained, m.p. 75-77 ° C. Example 6. Obtaining (2-dimethylaminoethoxy) -phenyl-3,3,3-trifluoro-1, 2-bis (4-hydroxy-1) -propene-hydrochloride. 4.0 g (7.47 mmol) of (2-dimershgaminoethoxy) phenyl-3,3,3-trifluoro-1, (4-methoxy-methoxyphenyl) propene in 40 ml of methanol with 10 ml of methanol hydrochloride are boiled in for an hour. The solution is concentrated to dryness and crystallized from Zta Iol. 2.67 g (74.4%) of the title compound are obtained. square 256-262 ° C. The starting product is obtained as follows; 18.72 g (46 mmol) of 1- (4-fluorofensch1) -E, 3,3-trifluoro-1,2-bis (4-methoxyphenyl) propane and 76 g of pyridine hydrochloride are heated at 200-. 210 ° C for 3 hours. The reaction mixture is cooled, diluted with 200 ml of chloroform and washed with water until neutral. The solution is dried and concentrated. The product obtained is dissolved in 200 mp of benzene, mixed with 11.1 g (138 mmol) of chloromethyl ether and 10 g (275 mmol) of powdered sodium hydroxide, and boiled for one hour. The reaction 32 mixture is diluted with 100 ml of benzene, dripped with a 20% solution of ammonium chloride and dried. The solution is sharpened, the residue is crystallized from isopropanol. 15.63 g (73%) of 1- (4-fluorophenyl) -3,3,3-trifluoro-1,2, -bis- (4-methoxy-methoxyphenyl) -projana are obtained, t. 1b, 106-107 C 6.0 g (12.9 mmol) of the obtained product in 30 ml of anhydrous benzene is mixed with 5.86 g (26 mmol) of 2,3-dichloro-5,6, dicyano-1, 4-benzoquinone and boiled in 28 hours. 4.42 g (74%) of 1- (4-fluorophenyl) -3,3,3-trifluoro-1, (4-methoxy-methoxy-phenyl) -propene are obtained, m.p. 73-74 0. 0.35 g (0.015 g-atom) of sodium is dissolved in 2.67 g (30 mmol) of dimethyl aminoethanol and the solution is introduced in interaction with the obtained product. 3.97 g (100%) of gummy (2-dimethylaminoethoxy) -phenyl-3, 3, 3-trifluoro-1,2-bis (-4-methoxy-methoxy-feil) -propene are obtained. Example 7. 2-Fensch-13, 3, 3-trifluoro-1- (4-hydroxyphenyl) (2-morpholinoethoxy) -phenyl propene radiation, 3.08 g (6 mmol) 2-feiyl-Z.Z. 3-trifluor -1- 4- (2-morpholinostoxy) phenyl} -1- (4-methoxy-methoxyphensh1) -propene in 40 ml of methanol and with 10 ml of 9% hydrochloric acid methanol bale - t for one hour. The solution is alkalinized 10 n. aqueous solution of sodium hydro and concentrated. The residue is dissolved in 400 ml of ether, washed to neutrality with water, dried and concentrated. The statistics are crystallized from acetone. 2.23 g (73.6%) of the title compound with m. Pl. 154-157 C. The starting product is obtained according to the procedure of Example 6. Example3. Preparation of 2-phenyl 3, 3,3-trifluoro-1 - (4-ox1-nyl) -1 - 4- (2-methylaminoethoxy) phenylT-propene hydrochloride. A solution of 1.50 g (3.28 mmol) of 2-feNSh1-3, 3,3-trifluoro-1-f 4- (2-metsh1-amino-ethoxy) -phenylZ-1- (4-methoxy-methoxyphenyl) -propene in 15 ml of methanol, together with 1.5 ml of 9% hydrochloric methanol, is boiled for one hour. The solution is evaporated to dryness and the residue is crystallized from isopropanol. To obtain 1.06 g of 71.6% of the title compound with m.p. 213-218 C, The starting product is obtained as follows (nm: 0.28 g (0.012 g-atom)
    sodium is dissolved in 2.70 g (36 mmol) of i-methylaminoethanol, then 2.36 g (5.86 mmol) of 2-fench1-3,3,3,3-trifluoro-1- (4-fluorophenl) -1 is added - (4-methoxy-methoxyphenyl) -propene. The reaction mixture 5 is heated at room temperature for one hour, cooled, diluted with 100 ml of ether, washed and dried. 1.94 g (72.4%) of 2-phenyl-3,3,3-trifluoro-1- 4- (2-methylaminoethoxy) -phenyl -1- (toxy-methoxyphenyl) -propene are obtained with a melting point of 87 -90 C.
    Example 9. Obtaining (E) -t, 2-diphenyl-3, 3,3-trifluoro-1-4-2-4- (2-hydroxyeth1) piperazino-ethoxy-phenyl-5-propene-mesylate,
    0.50 g (1 mmol) (E) -1,2-diphenyl-3,3, 37 trifluoro-1 g 4-2-4- (2-hydroxyethyl) piperazino-ethoxy-phenyl 5-propene is dissolved in 1 ml of isopropanol and 20 the solution is mixed with a solution of 0.2 g (2 mmol) of methane sulfonic acid in 2 ml of isopropanol. The precipitated crystals are filtered and washed with ether. 0.58 g (96.7) of the title compound are obtained with m. III. 203-209c.
    Example 10. Preparation of (E) -1- 4- (2-aminoethoxy) -phenyl-t1,2-difenst-3, 3,3-trifluoroprope n-trzilate.
    0.30 g (0.8 mmol) (E) (2-am-30 noethoxy) -phenyl -1,2-difenshen1-3,3,3-trifluoropropene is dissolved in 0.5 ml of isopropanol and the solution is mixed with the solution 0.20 g (1 mmol) P-toluenesulfonic acid in 1 ml of isopropanol. 35 The crystals that have been isolated are filtered out.
    and washed with ether. Obtain 0.37 g (84%) of the title compound with m.p. 162-163 0.
    Example 11. Preparation of (E) -1,2- 40 diphenyl-3,3,3-trifluoro-1-4-2- (2-hydroxyethylamino) -toxy-phenyl propenterate.
    0.21 g (0.5 Åmol) (E) 1,2-diphenyl-3, 3,3-trifluoro-1 - {4 - Q2- (2-ox syz TSH1-45 amino) -ethoxy 3-phenyl-propene dissolved in 0.2 ml of acetone, and the solution is mixed with a solution of 0.13 g (0.6 mmol) of citric acid hydrate in 0.8 ml of acetone. After cooling, the mixture was pe1; alkali sO mass was isolated: the crystals were filtered and washed with acetone. 0.18 g (58%) of the title compound is obtained with an mp. 127-129 0.
    Compounds prepared according to this 5S method suppressed the growth of 7,1-dimethylbenzantra-induced (DMBA) experimental breast tumors. The suppressive effect of new compounds on tumors is proved by the following tests. The following test compounds are tested:
    3. (E) -1,2-diphenyl-3,3,3-trifluoro-1-G4-12-bis- (2-hydroxyethyl) aminoethoxy-phenyl 3-propy;
    4. (E) -1,2-difenyl-3,3,3-difenyl-3, 3,3-trifluoro-1 4- 2- (4-methyl-piperazino) -ethoxy-phenyl-propy;
    5. (2-dimethylaminoethoxy) -phenyl-2-phenyl-3, 3,3-trifluoro-1- (4methoxyphenyl) -propene;
    6. (2-dimethylaminostoxy) -phenyl-2-phenyl-3, 3,3-trifluoro-1- (4-methoxyphenyl) propane;
    7. (E) -1,2-diphenyl-3,3,3-trifluoro-1-4-2- (2-oxyl-1-amino) -eTOKCifl-phenyl propene;
     8. (2-dimethylaminoethoxy) phenylJ-1-phenyl-3, 3, 3-trifluoro-2- (4-hydroxyphenyl) propene;
    9. (E) -1,2-diphenyl-3, 3,3-trifluoro-2-4- (2-pyrrolidino-ethoxy) -phenyl-propene;
    10. (E) -1,2-diphenyl-3,3,3-trifluoro-1-4- (2-morpholino-toxo) phenes1 propene;
    11. (E) -1- 4- (2-diethylaminoethoxy) | -phene1 -1,2-diphenyl-3,3,3-trifluoropropene;
    12.1- {4- (2-dimesh1-aminoethoxy) -phenyl-3, 3,3-trifluoro-1,2-bis (4-hydroxyphenyl) propene hydrochloride;
    13.1-phenyl-2- (4-methoxyphensh1) -1-4- (2-dimethylaminoethoxy) phenylJ-3, 3,3-trifluoropropene;
    14. (E) -1,2-d1 -enyl-3,3,3-trifluoro-1-4- (2-nitroguanidino) -ethoxy-Aenyl} -propene.
    Anti-estrogenic effect is defined as follows. Infantile female rats aged 24 days for 3 days are treated once daily with 5 mg / kg of estradiol subcutaneously (each group consists of 5 to animals). The test substance is also administered for 3 days once a day, daily by mouth. On the 4th day, the animals were sacrificed and after cleaning the weight of the uterus was measured.
    In tab. 1 illustrates the anti-estrogenic effect of certain compounds of formula I.
    II
    eleven
    As can be seen from the table. 1, the anti-estrogenic effect of some compounds is at the level of the known anti-estrogenic agents, clomiphene and tamoxifen.
    The hormone-dependent tumor effect of the compounds is determined by the example of 7,12-dimesh1-benz (a) anthracene (DMBA) induced breast carcinoma. The treatment begins with a tumor weight of 500 mg and is treated three times a week for a month at a dose of
    1433212
    20 mg / kg orally. Measurement of the tumor and observation of the animals is continued for 2 months after the end of the treatment period.
    For the evaluation of the effect, the relative efficiency index is introduced: this value is determined on the basis of counting the final baked or temporarily baked, animals with long or short remission.
    The results are presented in table. 2 Table 2
    1/5 3.5
    权利要求:
    Claims (1)
    [1]
    The method of obtaining derivatives
    1.1.2-triphenylpropene of the formula I cr 3 where X and y may be the same or different and mean each unsubstituted or substituted at the P-position of hydroxy, methoxy-methoxy-C ^ .- alkoxy- or benzyloxy groups of phenyl;
    Rj and - hydrogen, C 4 -alkyl or C -oxyalkyl or together with the nitrogen atom form a morpholine group, in the form of a mixture of isomers or a trans-isomer or their salts, characterized in that the compound of formula II where X and Y have the indicated meanings, with the exception of hydroxy groups, are reacted with an alkali metal alkanolate formulas
    P0-CH 2 -CH2 * 3 where M is an alkali metal;
    R ^ h have the indicated meanings in a bipolar aprotic
    1P4332
    ... I - - ”of a donor, such as dimethylacetamide, at 140-180 C, and, if necessary, the methoxy-methoxy- or benzyl-I-l-hydroxy group is split off under acidic conditions, and the target product is isolated as a mixture of isomers or trans-isomer into as a free compound or salt.
    The method of obtaining derivatives
    1,1,2-triphenylpropene in the form of a mixture of isomers or trans-isomer *, or their salts.
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    RU2569299C2|2009-05-19|2015-11-20|Атеникс,Инк.|Compositions for kinase cascade modulation and methods of their application|BE637389A|1962-09-13|
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    申请号 | 申请日 | 专利标题
    HU79GO1455A|HU178253B|1979-08-15|1979-08-15|Process for preparing 1,1,2-triphenyl-propane and -propane derivatives|
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